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Figure 3. Sildenafil improves the efficacy of ACT. BALB/c mice were challenged s.c. with either C26GM (A) or 4T1-HA (B) cells on day 0. Tumor-specific T cells were transferred on day 1. Sildenafil treatment was started on day 1. Tumors were surgically removed and weighed (right) either on day 10 (A) or 21 (B). *, PA < 0.00001 by using one-way ANOVA; +, PT < 0.001 by using a paired t test comparing sildenafil to sildenafil + ACT groups. Error bar values are shown.
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Following completion of this phase, the physician should be able to determine the medical status of the patient, to identify and characterize the type of dysfunction, and to determine the need for additional testing such as penile or pelvic blood flow studies, nocturnal penile tumescence testing, or other blood tests. The patient's needs, expectations, and priorities should be discussed in order to decide about further management or referral.
And if, like many women, you are used to your partner being the sexual initiator, this, say experts, may be the time for a little role-reversal.
"It's relatively common in men with diabetes and various forms of vascular disease, or men who've previously had infections -- usually infections of a penile prosthesis," Sharlip said. "There are men who have such severe fibrosis that nothing can be done to restore their natural erection function, other than to implant a surgical prosthesis," he added.
Prostatitis can cause pain and discomfort during and after ejaculation and plays a role in erectile dysfunction.
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The type of medical specialist who treats ED will depend on the cause of the problem. Based on your family's medical history as well as your own medical history and current health, your doctor may treat you with oral medications such as Viagra or similar drugs. If this fails, he or she may refer you to a urologist or psychologist.
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Because there are a variety of causes for ED, there are several different tests your doctor may use to diagnose the condition and determine its cause. Only after the cause of ED is determined can it be effectively treated.
The most common side effects of sildenafil are headache, flushing and dyspepsia (Table 4).17 A small percentage of patients report an alteration in color perception. Postmarketing reports released by the manufacturer indicate infrequent occurrences of priapism. Because of the presence of phosphodiesterase in the retina, patients with retinitis pigmentosa should not be given sildenafil.
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